MycoWeekly Newsletter

Your Weekly Dose of Mycology Research

Sustainable Encapsulation of Bacillus velezensis FZB42 Using Tunicate-Derived Carboxymethylcellulose Hydrogels for Enhanced Biocontrol Efficiency.

2025-07-14
Biomacromolecules • Level 2 (10 panels)
Sol Ji Park, S. Moon, Bum Jun Jang, Sang Hyun Lee, Hwa Sung Shin, Yun Jung Yang

This study investigates the use of tunicate-derived carboxymethylcellulose hydrogels to encapsulate Bacillus velezensis FZB42 spores, aiming to enhance biocontrol against alkaline-favoring fungal pathogens like Fusarium graminearum. By improving spore stability and offering controlled release, this method provides an eco-friendly strategy, utilizing marine waste for sustainable agriculture.

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Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction

2025-03-12
eLife • Level 2 (11 panels)
J. Boocock, Noah Alexander, Leslie Alamo Tapia, Laura Walter-McNeill, Shivani Prashant Patel, Chetan Munugala, Joshua S. Bloom, Leonid Kruglyak

Expression quantitative trait loci (eQTLs) link noncoding DNA variants to phenotypic traits. Utilizing single-cell RNA sequencing (scRNA-seq) in yeast, researchers identified eQTL interactions with cell-cycle stages, mapping key loci impacting cell-cycle progression. Notably, a GPA1 variant boosts mating efficiency while hindering growth, suggesting evolutionary trade-offs in outcrossing contexts.

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The molecular logic of Gtr1/2- and Pib2-dependent TORC1 regulation in budding yeast

2025-07-07
eLife • Level 2 (11 panels)
Jacob H. Cecil, Cristina M. Padilla, Austin A. Lipinski, Paul Langlais, Xiangxia Luo, A. Capaldi

In Saccharomyces cerevisiae, the Target of Rapamycin kinase Complex 1 (TORC1) is modulated by Gtr1/2 GTPases and Pib2 protein, dictating growth states. New findings reveal three TORC1 states: rapid growth with both regulators on, adaptive growth with only Pib2 on, and quiescence with both off. This nuanced control hints at overlooked multistate pathways in kinase signaling.

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Force transmission through the inner kinetochore is enhanced by centromeric DNA sequences

2025-05-29
eLife • Level 2 (11 panels)
Elise Miedlar, G. Hamilton, S. Witus, Sara J Gonske, M. Riffle, A. Zelter, Rachel E. Klevit, C. Asbury, Yoana N Dimitrova, Trisha N. Davis

A kinetochore is a protein structure on chromatids where the spindle fibers attach during cell division, crucial for chromosome segregation. This study reveals that centromeric DNA sequences in Saccharomyces cerevisiae enhance force transmission through the Okp1/Ame1 complex in the inner kinetochore. These sequences fortify the linkage of microtubule forces to chromosomes, underscoring their essential role in chromosome stability.

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