Your Weekly Dose of Mycology Research
Your Weekly Dose of Mycology Research
This study explores gut microbiota – the bacterial and fungal communities in the digestive tract – in foals, revealing decreased microbial diversity during diarrhea. Significant reductions in probiotic genera like Bifidobacterium and Saccharomyces were found, emphasizing the potential of probiotics over antibiotics in managing foal diarrhea through gut microbiota modulation.
The Whi2-Psr1-Psr2 complex plays an essential role in regulating Target of Rapamycin Complex 1 (TORC1) and autophagy in yeast, particularly under low leucine conditions, but not during nitrogen depletion. Remarkably, human HAD phosphatases CTDSP1, CTDSP2, and CTDSPL can substitute for Psr1 and Psr2, restoring TORC1 inhibition and autophagy, highlighting evolutionary parallels in metabolic responses.
Galleria mellonella larvae, an invertebrate model, are employed in assessing fungal virulence. This study explores the pathogenic potential of 19 Aspergillus species from the Terrei section, organized into Terrei, Nivei, and Ambigui clades. Findings indicate notable virulence variability across clades, with certain cryptic species exhibiting heightened pathogenicity, underscoring the complexity within Aspergillus section Terrei.
The G-protein coupled receptor (GPCR) antagonist PPTN, when combined with caspofungin (CAS), demonstrates enhanced fungicidal effects against Aspergillus fumigatus resistant strains. This synergy not only targets CAS- and voriconazole-resistant A. fumigatus but also extends to Candida species, positioning PPTN as a promising adjuvant in antifungal therapy.